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// The Desk · Overall dispatch · Filed August 2026

Best GLP-1 for weight loss — ranked before you've picked a molecule.

Not filtered to semaglutide or tirzepatide — every one of the Desk's 498providers scored on the same six factors, whichever molecule they dispense. Below the board: which of the top entries actually let you access more than one option from a single account.

// If you meant the drug, not the provider

This board ranks providers on operational factors — price transparency, state access, licensing — not clinical weight-loss outcomes. If the question is which drug produces more weight loss, that is a trial-evidence question answered in semaglutide vs tirzepatide, not one a provider-comparison board can honestly settle.

// Overall board

10 entries · desk score · August 2026

CoreAge Rx leads the board at 94/100. Semaglutide: $149/mo. Tirzepatide: $349/mo. No oral option is on file for this provider.

Open CoreAge Rx ↗
  1. 01

    CoreAge Rx

    MOLECULES 2/394·AOpen ↗
  2. 02

    Strut Health

    MOLECULES 3/388·B+Open ↗
  3. 03

    Sesame Care

    MOLECULES 2/387·B+Open ↗
  4. 04

    HealthRX

    MOLECULES 3/386·BOpen ↗
  5. 05

    RxSpan MD

    MOLECULES 3/386·BOpen ↗
  6. 06

    Sprout Health

    MOLECULES 2/386·BOpen ↗
  7. 07

    MadeMed

    MOLECULES 3/386·BOpen ↗
  8. 08

    Enhance MD

    MOLECULES 2/385·BOpen ↗
  9. 09

    Telos Rx

    MOLECULES 3/385·BOpen ↗
  10. 10

    ShedRx

    MOLECULES 3/385·BOpen ↗

// Assume any provider we log may compensate us. We may earn a referral commission if you start care through some of these links, at no extra cost to you — what we file on a provider reads the same either way. Full disclosure.

// The finding

Scoring first, molecule second — does that leave you boxed in?

Of this board's 10 top-scored entries, 9 file a real price for both semaglutide and tirzepatide, and 7 also offer an oral option — compared with 315 of 498 and 128 of 498 across the whole roster. In plain terms: ranking on operational factors rather than molecule access has not, on this data, produced a top board that boxes you into one drug — the highest scorers are disproportionately the ones that let you compare both figures from a single account before committing to either.

The dispatches

The top 6 entries in full — what each is for, and what the Desk marked it down on.

  1. #1

    CoreAge Rx

    The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.

    Semaglutide:
    $149/mo
    Tirzepatide:
    $349/mo
    Oral option:
    Injectable only
    States:
    All 50 states

    Best for: Anyone who wants a verified flat price and full nationwide reach from day one.

    Marked down on: Not the lowest sticker price on the board

    Open CoreAge Rx ↗Read the full dispatch
  2. #2

    Strut Health

    The same molecule as a lozenge or an injection at the same price — the only place on this board where the needle is genuinely optional.

    Semaglutide:
    From $99/mo sublingual, $149/mo injectable
    Tirzepatide:
    From $199/mo either route
    Oral option:
    Yes
    States:
    49 states (not Arkansas)

    Best for: People whose real objection is the needle rather than the medicine, and who want every route priced before signing up.

    Marked down on: Asynchronous by design — their FAQ notes some states need no phone consultation, so you may never speak to the prescriber

    Open Strut Health ↗Read the full dispatch
  3. #3

    Sesame Care

    An established national telehealth marketplace with the widest real brand-name GLP-1 access on the board — Wegovy (pen and pill), Zepbound, Ozempic and Mounjaro — plus provider-by-provider price transparency.

    Semaglutide:
    From $149/mo (brand Wegovy pill)
    Tirzepatide:
    Brand Zepbound (price varies)
    Oral option:
    Yes
    States:
    Nationwide marketplace

    Best for: Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.

    Marked down on: A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk

    Open Sesame Care ↗Read the full dispatch
  4. #4

    HealthRX

    A LegitScript-certified telehealth desk with a rare oral GLP tablet route alongside injectables and physician-reviewed intake.

    Semaglutide:
    $189/mo (compounded)
    Tirzepatide:
    $349/mo (GLP+GIP)
    Oral option:
    Yes
    States:
    United States

    Best for: Patients who want a certified, physician-supervised program and the option of an oral tablet instead of an injection.

    Marked down on: Compounded medications are not FDA-approved

    Open HealthRX ↗Read the full dispatch
  5. #5

    RxSpan MD

    A physician-founded desk with one of the widest menus on the board — compounded and brand-name GLP-1 across injectable and oral routes, microdosing, plus longevity, hair, and sexual-health lines — with transparent, all-inclusive pricing across all 50 states.

    Semaglutide:
    From $194/mo
    Tirzepatide:
    $329/mo
    Oral option:
    Yes
    States:
    All 50 states

    Best for: Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach.

    Marked down on: Compounded semaglutide and tirzepatide are not FDA-approved — not the same as Wegovy/Ozempic or Zepbound

    Open RxSpan MD ↗Read the full dispatch
  6. #6

    Sprout Health

    A LegitScript-certified desk that pairs low-cost compounded semaglutide and tirzepatide with a real brand-name Wegovy and Zepbound path — and a near-frictionless, often visit-free start.

    Semaglutide:
    $149/mo
    Tirzepatide:
    $199/mo
    Oral option:
    Injectable only
    States:
    Not disclosed

    Best for: Patients who want a low compounded entry price but the option of brand-name Wegovy or Zepbound on the same account, with minimal onboarding.

    Marked down on: Compounded semaglutide and tirzepatide are not FDA-approved

    Open Sprout Health ↗Read the full dispatch

Best GLP-1 for weight loss, answered

What is the best GLP-1 for weight loss?
"Best" splits into two different questions here. If you mean the drug: semaglutide and tirzepatide are both GLP-1-class medications, and clinical trials generally show tirzepatide producing greater average weight loss — see our molecule-by-molecule breakdown in semaglutide vs tirzepatide. If you mean the provider — which is what this board ranks — CoreAge Rx leads at a Desk Score of 94/100, scored on the same six factors regardless of which molecule you eventually pick.
Should I pick a provider before or after picking a molecule?
Either is workable, but this board exists for readers who have not decided yet. 315 of the Desk's 498 providers file a price for both semaglutide and tirzepatide, so starting with a flexible provider does not lock you into one drug — you can compare both figures on the same account before committing. 128 providers also offer an oral option for readers who would rather not inject.
Does the Desk rank GLP-1 providers by weight-loss results?
No. The Desk Score measures six operational factors — price transparency, state access, molecule range, onboarding speed, support responsiveness, and licensing and trust (see our methodology) — not clinical weight-loss outcomes, which vary by patient and are not something a provider comparison site can honestly measure or claim to rank.
What is the cheapest option among the top-ranked providers?
Among this board's top 10, Strut Health files the lowest disclosed figure, at $99/mo. This board ranks on the Desk Score, not price — see /best/cheapest-glp-1 for the board sorted strictly by price instead.

// The Desk's other boards

Background reading: weigh the molecules in semaglutide vs tirzepatide, decide between an injection and an oral option, check an operator against how to tell if a provider is legitimate, or see the best-for-X picks in best GLP-1 provider by need. You can also compare any two providers head-to-head.

Prices and coverage are each provider's own public filings at last review and change without notice. Scores follow the Desk's published methodology. Informational, not medical advice; compounded medications are not FDA-approved brand products. See our medical disclaimer.