Alternatives to Open Water Rx

A physician-founded desk with one of the widest menus in the ranking — compounded and brand-name GLP-1 across injectable and oral routes, microdosing, plus longevity, hair, and sexual-health lines — with transparent, all-inclusive pricing across all 50 states.

Marked down on: You pay before a clinician reads your intake, and RxSpan MD publishes no refund policy — the word "refund" appears nowhere on the site, and the terms of service say only that you agree to pay all fees. The cheapest advertised rate is a single upfront payment of $2,094 for a year of semaglutide, and the plan card says it auto-renews

$249/mo sema · $329/mo tirz

He & She MD is a nationwide telehealth weight-loss clinic offering doctor-prescribed GLP-1 medications: compounded semaglutide and tirzepatide (injectable or oral) with brand-name Ozempic and Zepbound alongside, on a published 1/3/6/12-month plan table.

Marked down on: Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap

$249/mo sema · $339/mo tirz

NuDay Rx is a GLP-1 weight-loss telehealth service (on the CareValidate/careGLP platform) that pairs medication with video coaching and lifestyle support.

Marked down on: Compounded semaglutide ($249) is pricier than some budget competitors

$249/mo sema · $329/mo tirz

A multi-program telehealth brand with a full per-4-week price list published for every GLP-1 molecule and route — compounded and brand-name Ozempic, injection and tablet — plus a separate NAD+/sermorelin longevity line, also available.

Marked down on: Price varies significantly by molecule, route and term length — the 4-week rate runs meaningfully higher per week than the 12/24/52-week commitments, a real lock-in tradeoff to weigh before choosing a term

$249 per 4 weeks sema · $339 per 4 weeks tirz

Wisp (hellowisp.com) is a large women's telehealth service whose weight care aisle offers brand-name Wegovy, Zepbound and Saxenda written for your own pharmacy, plus compounded sublingual semaglutide drops at $225/month on top of a recurring $99/month consult.

Marked down on: The consult is a separate, recurring $99/month charge that the product card does not show, so the real cost of the sublingual program is $324/mo — well above a compounded injection at most sellers, for the weaker formulation

$225/mo (+ membership fee) sema