Head-to-head dispatch
OnlyRx vs ShedRx
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
OnlyRx is a cash-pay GLP-1 telehealth platform offering compounded semaglutide and tirzepatide in both injection and oral disintegrating tablet (ODT) forms — an uncommon needle-free option.
$179/mo (starting dose, promotional rate, compounded) sema · $249/mo (starting dose, compounded) tirz · Verified July 25, 2026
Marked down on: Promo pricing ($179 semaglutide injection) is prominent, but post-promo maintenance pricing isn't shown
Desk Score
Widest formulation spread in the ranking — injection, liquid drops, lozenges and a daily oral pill, plus a real brand Zepbound lane.
$199/mo sema · $299/mo tirz
Marked down on: The advertised "as low as $239" tirzepatide rate needs a twelve-month commitment — month-to-month is $299
ShedRx takes this head-to-head with the higher Desk Score, 85/100 (B) against 65/100 (C) for OnlyRx. OnlyRx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
OnlyRx
65/100
C
ShedRx
85/100
B
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | OnlyRx | ShedRx |
|---|---|---|
| Semaglutide | $179/mo (starting dose, promotional rate, compounded) | $199/mo |
| Tirzepatide | $249/mo (starting dose, compounded) | $299/mo |
| Coverage | Not listed on OnlyRx's site (checked July 25, 2026) | All 50 states |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Compounded GLP-1 in oral-tablet and injection with named prescribers. | People who want a needle-free route or a brand-name option without leaving one provider. |
| Desk Score | 65/100C | 85/100B |
The verdict
Desk pick — ShedRxShedRx takes this head-to-head with the higher Desk Score, 85/100 (B) against 65/100 (C) for OnlyRx. OnlyRx still holds its ground where its strengths line up with yours.
Choose OnlyRx if…
Compounded GLP-1 in oral-tablet and injection with named prescribers.
$179/mo (starting dose, promotional rate, compounded) sema · $249/mo (starting dose, compounded) tirz
Choose ShedRx if…
People who want a needle-free route or a brand-name option without leaving one provider.
$199/mo sema · $299/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: OnlyRx · ShedRx.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: one price at every dose, both molecules, all 50 states — but the $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs OnlyRx
- CoreAge Rx vs ShedRx
- OnlyRx vs Vaylen
- ShedRx vs Vaylen
- OnlyRx vs RxSpan MD
- RxSpan MD vs ShedRx
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.