Head-to-head comparison
Shed vs Synergy Rx
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Widest formulation spread in the ranking — injection, liquid drops, lozenges and a daily oral pill, plus a real brand Zepbound lane.
$199/mo sema · $299/mo tirz · Verified August 2026
Marked down on: The advertised "as low as $239" tirzepatide rate needs a twelve-month commitment — month-to-month is $299
Desk Score
Brand Wegovy, Ozempic or Mounjaro when clinically appropriate, with unlimited round-the-clock clinical contact.
From $199 sema · From $349 tirz · Verified August 2026
Marked down on: Prints only "Starting at" figures — $199 semaglutide, $349 tirzepatide — with no billing cycle, term or dose, and its FAQ says the price is provided after the consultation
Shed takes this head-to-head with the higher Desk Score, 88/100 (B+) against 72/100 (C) for Synergy Rx. Synergy Rx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Shed
88/100
B+
Synergy Rx
72/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Shed | Synergy Rx |
|---|---|---|
| Semaglutide | $199/mo$199/mo month-to-month ($179/mo on the 6-month plan, $159/mo on the 12-month plan — both carry a minimum term whose shipped cycles are non-refundable) | From $199From $199 (the Weight Loss tab on synergyrx.co/products prints "Starting at $199" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) |
| Tirzepatide | $299/mo$299/mo month-to-month ($269/mo on the 6-month plan, $239/mo on the 12-month plan — both carry a minimum term whose shipped cycles are non-refundable) | From $349From $349 (the Weight Loss tab on synergyrx.co/products prints "Starting at $349" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) |
| Coverage | All 50 states (no state list is published on the site) | All 50 states per its FAQ (its terms say to email support for the current list) |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | People who want a needle-free route or a brand-name option without leaving one provider. | People who want a brand-name lane and as much clinician access as possible, and will get pricing by inquiry. |
| Desk Score | 88/100B+ | 72/100C |
The verdict
Desk pick — ShedShed takes this head-to-head with the higher Desk Score, 88/100 (B+) against 72/100 (C) for Synergy Rx. Synergy Rx still holds its ground where its strengths line up with yours.
Choose Shed if…
People who want a needle-free route or a brand-name option without leaving one provider.
$199/mo sema · $299/mo tirz · All 50 states (no state list is published on the site)
Choose Synergy Rx if…
People who want a brand-name lane and as much clinician access as possible, and will get pricing by inquiry.
From $199 sema · From $349 tirz · All 50 states per its FAQ (its terms say to email support for the current list)
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Shed · Synergy Rx.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs Shed
- CoreAge Rx vs Synergy Rx
- Shed vs Vaylen
- Synergy Rx vs Vaylen
- Curex vs Shed
- Synergy Rx vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.