Head-to-head dispatch
RxSpan MD vs Synergy Rx
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
A physician-founded desk with one of the widest menus in the ranking — compounded and brand-name GLP-1 across injectable and oral routes, microdosing, plus longevity, hair, and sexual-health lines — with transparent, all-inclusive pricing across all 50 states.
From $194/mo sema · $329/mo tirz
Marked down on: Compounded semaglutide and tirzepatide are not FDA-approved — not the same as Wegovy/Ozempic or Zepbound
Desk Score
Brand Wegovy, Ozempic or Mounjaro when clinically appropriate, with unlimited round-the-clock clinical contact.
From $199 (the Weight Loss tab on synergyrx.co/products prints "Starting at $199" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) sema · From $349 (the Weight Loss tab on synergyrx.co/products prints "Starting at $349" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) tirz · Verified August 29, 2026
Marked down on: Prints only "Starting at" figures — $199 semaglutide, $349 tirzepatide — with no billing cycle, term or dose, and its FAQ says the price is provided after the consultation
RxSpan MD takes this head-to-head with the higher Desk Score, 86/100 (B) against 75/100 (C) for Synergy Rx. Synergy Rx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
RxSpan MD
86/100
B
Synergy Rx
75/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | RxSpan MD | Synergy Rx |
|---|---|---|
| Semaglutide | From $194/mo | From $199 (the Weight Loss tab on synergyrx.co/products prints "Starting at $199" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) |
| Tirzepatide | $329/mo | From $349 (the Weight Loss tab on synergyrx.co/products prints "Starting at $349" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) |
| Coverage | All 50 states | All 50 states per its FAQ (its terms say to email support for the current list) |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach. | People who want a brand-name lane and as much clinician access as possible, and will get pricing by inquiry. |
| Desk Score | 86/100B | 75/100C |
The verdict
Desk pick — RxSpan MDRxSpan MD takes this head-to-head with the higher Desk Score, 86/100 (B) against 75/100 (C) for Synergy Rx. Synergy Rx still holds its ground where its strengths line up with yours.
Choose RxSpan MD if…
Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach.
From $194/mo sema · $329/mo tirz · All 50 states
Choose Synergy Rx if…
People who want a brand-name lane and as much clinician access as possible, and will get pricing by inquiry.
From $199 (the Weight Loss tab on synergyrx.co/products prints "Starting at $199" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) sema · From $349 (the Weight Loss tab on synergyrx.co/products prints "Starting at $349" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) tirz · All 50 states per its FAQ (its terms say to email support for the current list)
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: RxSpan MD · Synergy Rx.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: one price at every dose, both molecules, all 50 states — but the $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs RxSpan MD
- CoreAge Rx vs Synergy Rx
- RxSpan MD vs Vaylen
- Synergy Rx vs Vaylen
- RxSpan MD vs Semaglutide Online
- Synergy Rx vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.