Head-to-head comparison
Synergy Rx vs Vaylen
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Brand Wegovy, Ozempic or Mounjaro when clinically appropriate, with unlimited round-the-clock clinical contact.
From $199 sema · From $349 tirz · Verified August 2026
Marked down on: Prints only "Starting at" figures — $199 semaglutide, $349 tirzepatide — with no billing cycle, term or dose, and its FAQ says the price is provided after the consultation
Desk Score
The strongest all-rounder among the newer entrants — low pricing, brand access, oral routes, and all 50 states on one account.
$179/mo sema · $239/mo tirz
Marked down on: Newer operator with a shorter track record
Vaylen takes this head-to-head with the higher Desk Score, 90/100 (A−) against 72/100 (C) for Synergy Rx. Synergy Rx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Synergy Rx
72/100
C
Vaylen
90/100
A−
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Synergy Rx | Vaylen |
|---|---|---|
| Semaglutide | From $199From $199 (the Weight Loss tab on synergyrx.co/products prints "Starting at $199" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) | $179/mo$179/mo |
| Tirzepatide | From $349From $349 (the Weight Loss tab on synergyrx.co/products prints "Starting at $349" with no term, dose or billing cycle; the FAQ says the price is given after the consultation; compounded injectable) | $239/mo$239/mo |
| Coverage | All 50 states per its FAQ (its terms say to email support for the current list) | All 50 states |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | People who want a brand-name lane and as much clinician access as possible, and will get pricing by inquiry. | People who want maximum optionality — brand or compounded, oral or injectable — without giving up nationwide reach. |
| Desk Score | 72/100C | 90/100A− |
The verdict
Desk pick — VaylenVaylen takes this head-to-head with the higher Desk Score, 90/100 (A−) against 72/100 (C) for Synergy Rx. Synergy Rx still holds its ground where its strengths line up with yours.
Choose Synergy Rx if…
People who want a brand-name lane and as much clinician access as possible, and will get pricing by inquiry.
From $199 sema · From $349 tirz · All 50 states per its FAQ (its terms say to email support for the current list)
Choose Vaylen if…
People who want maximum optionality — brand or compounded, oral or injectable — without giving up nationwide reach.
$179/mo sema · $239/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Synergy Rx · Vaylen.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
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Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.