Head-to-head comparison
Renlo Health vs Signos
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
One of the few programs whose headline is the actual monthly rate, with the prescribing physician and the dispensing pharmacy both named.
$199/mo (see conditions) sema · $269/mo (see conditions) tirz · Verified September 2026
Marked down on: A struck-through $399 sits beside the price with no published basis — Renlo never says what it was, when it applied or to whom.
Desk Score
Signos (Signos+) is a metabolic-health platform that bundles clinician-prescribed compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor (CGM) and app.
$199/mo (6-month prepay) sema · From $199/mo (lowest dose rung) tirz · Verified July 2026
Marked down on: Compounded GLP-1s are not FDA-approved finished products
Renlo Health takes this head-to-head with the higher Desk Score, 80/100 (B−) against 62/100 (C) for Signos. Signos still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Renlo Health
80/100
B−
Signos
62/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Renlo Health | Signos |
|---|---|---|
| Semaglutide | $199/mosee conditions$199/mo (compounded, billed monthly at every dose) | $199/mo6-month prepay$199/mo (6-month plan, compounded) |
| Tirzepatide | $269/mosee conditions$269/mo (compounded, billed monthly at every dose) | From $199/molowest dose rung$199/mo (starting dose, compounded) |
| Coverage | Not listed on Renlo Health's site (checked September 2026) | Not listed on Signos's site (checked July 2026) |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Someone who wants a flat monthly bill, a named prescriber and a refund route, and can ignore an anchor nobody explains. | Pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app. |
| Desk Score | 80/100B− | 62/100C |
The verdict
Desk pick — Renlo HealthRenlo Health takes this head-to-head with the higher Desk Score, 80/100 (B−) against 62/100 (C) for Signos. Signos still holds its ground where its strengths line up with yours.
Choose Renlo Health if…
Someone who wants a flat monthly bill, a named prescriber and a refund route, and can ignore an anchor nobody explains.
$199/mo (see conditions) sema · $269/mo (see conditions) tirz
Choose Signos if…
Pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app.
$199/mo (6-month prepay) sema · From $199/mo (lowest dose rung) tirz
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Renlo Health · Signos.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs Renlo Health
- CoreAge Rx vs Signos
- HealthRX vs Renlo Health
- HealthRX vs Signos
- Renlo Health vs Welling Health
- RestorLife Med vs Signos
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.