Head-to-head dispatch
HealthRX vs Signos
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
A LegitScript-certified compounding platform whose pricing page prints every plan's total, per-month rate and renewal price — and whose renewals are cheaper than sign-up.
$190/mo month-to-month ($149 first month on Subscribe & Save, renews at $165) · $99/mo on a 12-month prepay ($1,188) sema · $239/mo month-to-month ($193 first month on Subscribe & Save, renews at $214) · $179/mo on a 12-month prepay ($2,148) tirz · Verified August 29, 2026
Marked down on: Compounded medications are not FDA-approved
Desk Score
Signos (Signos+) is a metabolic-health platform that bundles clinician-prescribed compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor (CGM) and app.
$199/mo (6-month plan, compounded) sema · $199/mo (starting dose, compounded) tirz · Verified July 25, 2026
Marked down on: Compounded GLP-1s are not FDA-approved finished products
HealthRX takes this head-to-head with the higher Desk Score, 86/100 (B) against 62/100 (C) for Signos. Signos still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
HealthRX
86/100
B
Signos
62/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | HealthRX | Signos |
|---|---|---|
| Semaglutide | $190/mo month-to-month ($149 first month on Subscribe & Save, renews at $165) · $99/mo on a 12-month prepay ($1,188) | $199/mo (6-month plan, compounded) |
| Tirzepatide | $239/mo month-to-month ($193 first month on Subscribe & Save, renews at $214) · $179/mo on a 12-month prepay ($2,148) | $199/mo (starting dose, compounded) |
| Coverage | All 50 states | Not listed on Signos's site (checked July 25, 2026) |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Patients who want a certified program with every plan price and renewal in one table, and a full refund if a provider does not approve them. | Pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app. |
| Desk Score | 86/100B | 62/100C |
The verdict
Desk pick — HealthRXHealthRX takes this head-to-head with the higher Desk Score, 86/100 (B) against 62/100 (C) for Signos. Signos still holds its ground where its strengths line up with yours.
Choose HealthRX if…
Patients who want a certified program with every plan price and renewal in one table, and a full refund if a provider does not approve them.
$190/mo month-to-month ($149 first month on Subscribe & Save, renews at $165) · $99/mo on a 12-month prepay ($1,188) sema · $239/mo month-to-month ($193 first month on Subscribe & Save, renews at $214) · $179/mo on a 12-month prepay ($2,148) tirz · All 50 states
Choose Signos if…
Pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app.
$199/mo (6-month plan, compounded) sema · $199/mo (starting dose, compounded) tirz
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: HealthRX · Signos.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: one price at every dose, both molecules, all 50 states — but the $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs HealthRX
- CoreAge Rx vs Signos
- HealthRX vs Trimi
- Breeze Meds vs Signos
- Elara Health and Wellness vs HealthRX
- NiceRx vs Signos
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.