Head-to-head comparison
PlexusDx vs Tyde Wellness
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
PlexusDx (plexusdx.com) is a US GLP-1 telehealth platform offering compounded weight-loss medications with licensed providers in all 50 states.
From $149/mo (lowest dose rung) sema · From $249/mo (lowest dose rung) tirz · Verified July 2026
Marked down on: Compounded medications only; no FDA-approved brand options
Desk Score
Compounded semaglutide from $149 a month and tirzepatide from $249, sold as a membership with nutrition coaching, a free consultation, and five named pharmacies — but no published dose ladder.
From $149/mo sema · From $249/mo tirz · Verified August 2026
Marked down on: No brand-name access
Tyde Wellness takes this head-to-head with the higher Desk Score, 90/100 (A−) against 75/100 (C) for PlexusDx. PlexusDx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
PlexusDx
75/100
C
Tyde Wellness
90/100
A−
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | PlexusDx | Tyde Wellness |
|---|---|---|
| Semaglutide | From $149/molowest dose rung$149/mo (starting dose, compounded) | From $149/moFrom $149/mo, billed as a recurring membership (monthly or every 4 weeks); no dose ladder published; compounded injectable |
| Tirzepatide | From $249/molowest dose rung$249/mo (starting dose, compounded) | From $249/moFrom $249/mo, billed as a recurring membership (monthly or every 4 weeks); no dose ladder published; compounded injectable |
| Coverage | All 50 states | All 50 states |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Shoppers wanting nationwide compounded GLP-1 with optional genetic-test personalization. | Someone who wants coaching and a clinician visit bundled with the prescription, and who will confirm the real monthly figure on the consult before enrolling. |
| Desk Score | 75/100C | 90/100A− |
The verdict
Desk pick — Tyde WellnessTyde Wellness takes this head-to-head with the higher Desk Score, 90/100 (A−) against 75/100 (C) for PlexusDx. PlexusDx still holds its ground where its strengths line up with yours.
Choose PlexusDx if…
Shoppers wanting nationwide compounded GLP-1 with optional genetic-test personalization.
From $149/mo (lowest dose rung) sema · From $249/mo (lowest dose rung) tirz · All 50 states
Choose Tyde Wellness if…
Someone who wants coaching and a clinician visit bundled with the prescription, and who will confirm the real monthly figure on the consult before enrolling.
From $149/mo sema · From $249/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: PlexusDx · Tyde Wellness.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs PlexusDx
- CoreAge Rx vs Tyde Wellness
- Ondra Health vs PlexusDx
- Ondra Health vs Tyde Wellness
- PlexusDx vs Trellis Vitality
- Tyde Wellness vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.