Head-to-head comparison
PlexusDx vs Trellis Vitality
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
PlexusDx (plexusdx.com) is a US GLP-1 telehealth platform offering compounded weight-loss medications with licensed providers in all 50 states.
From $149/mo (lowest dose rung) sema · From $249/mo (lowest dose rung) tirz · Verified July 2026
Marked down on: Compounded medications only; no FDA-approved brand options
Desk Score
Trellis Vitality prices both molecules flat at every dose before intake and names its pharmacy and prescriber, while its own GLP-1 FAQ contradicts the all-50-states banner above it.
From $150/mo sema · From $199/mo tirz · Verified September 2026
Marked down on: The banner says all 50 states while the GLP-1 program's own FAQ says it is not offered in every state, naming Connecticut, Ohio and South Carolina.
Trellis Vitality takes this head-to-head with the higher Desk Score, 81/100 (B−) against 75/100 (C) for PlexusDx. PlexusDx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
PlexusDx
75/100
C
Trellis Vitality
81/100
B−
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | PlexusDx | Trellis Vitality |
|---|---|---|
| Semaglutide | From $149/molowest dose rung$149/mo (starting dose, compounded) | From $150/moFrom $150/mo (all doses, compounded) |
| Tirzepatide | From $249/molowest dose rung$249/mo (starting dose, compounded) | From $199/moFrom $199/mo (all doses, compounded) |
| Coverage | All 50 states | All 50 states claimed; GLP-1 not offered in every state |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Shoppers wanting nationwide compounded GLP-1 with optional genetic-test personalization. | Anyone who wants a flat dose price and will check whether their state is one the GLP-1 program actually covers. |
| Desk Score | 75/100C | 81/100B− |
The verdict
Desk pick — Trellis VitalityTrellis Vitality takes this head-to-head with the higher Desk Score, 81/100 (B−) against 75/100 (C) for PlexusDx. PlexusDx still holds its ground where its strengths line up with yours.
Choose PlexusDx if…
Shoppers wanting nationwide compounded GLP-1 with optional genetic-test personalization.
From $149/mo (lowest dose rung) sema · From $249/mo (lowest dose rung) tirz · All 50 states
Choose Trellis Vitality if…
Anyone who wants a flat dose price and will check whether their state is one the GLP-1 program actually covers.
From $150/mo sema · From $199/mo tirz · All 50 states claimed; GLP-1 not offered in every state
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: PlexusDx · Trellis Vitality.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs PlexusDx
- CoreAge Rx vs Trellis Vitality
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- Ondra Health vs Trellis Vitality
- PlexusDx vs Tyde Wellness
- Trellis Vitality vs Tyde Wellness
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.