Head-to-head dispatch
Enhance MD vs System Labs
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
The clearest tiered compounded pricing in the ranking — separate lines for sema, tirzepatide, a microdose tier, and a sema+tirz combo — with lab testing built in.
Marked down on: Compounded only — not FDA-approved
Desk Score
One molecule, one route, one price — a flat $179/mo tirzepatide subscription with the rate written out in the provider's own words rather than teased as a floor.
Marked down on: One molecule only — the program is a compounded tirzepatide-based GLP-1/GIP and there is no semaglutide product at all, so switching molecules means switching provider
Enhance MD takes this head-to-head with the higher Desk Score, 85/100 (B) against 75/100 (C) for System Labs. System Labs still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Enhance MD
85/100
B
System Labs
75/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Enhance MD | System Labs |
|---|---|---|
| Semaglutide | $249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepay | Not offered — no semaglutide product |
| Tirzepatide | $329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepay | $179/mo standing (compounded, all doses) |
| Coverage | Not publicly listed | Not disclosed |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Patients who want fully itemized compounded options and ongoing metabolic oversight, and don't need brand-name or oral routes. | Readers who only want tirzepatide, want the monthly number settled before they start, and will not miss a semaglutide, oral or brand-name option. |
| Desk Score | 85/100B | 75/100C |
The verdict
Desk pick — Enhance MDEnhance MD takes this head-to-head with the higher Desk Score, 85/100 (B) against 75/100 (C) for System Labs. System Labs still holds its ground where its strengths line up with yours.
Choose Enhance MD if…
Patients who want fully itemized compounded options and ongoing metabolic oversight, and don't need brand-name or oral routes.
$249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepay sema · $329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepay tirz · Not publicly listed
Choose System Labs if…
Readers who only want tirzepatide, want the monthly number settled before they start, and will not miss a semaglutide, oral or brand-name option.
Not offered — no semaglutide product sema · $179/mo standing (compounded, all doses) tirz · Not disclosed
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: Enhance MD · System Labs.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.
More head-to-heads
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- System Labs vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.