Head-to-head dispatch
OnlyRx vs RxSpan MD
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
OnlyRx is a cash-pay GLP-1 telehealth platform offering compounded semaglutide and tirzepatide in both injection and oral disintegrating tablet (ODT) forms — an uncommon needle-free option.
Marked down on: Promo pricing ($179 semaglutide injection) is prominent, but post-promo maintenance pricing isn't shown
Desk Score
A physician-founded desk with one of the widest menus in the ranking — compounded and brand-name GLP-1 across injectable and oral routes, microdosing, plus longevity, hair, and sexual-health lines — with transparent, all-inclusive pricing across all 50 states.
Marked down on: Compounded semaglutide and tirzepatide are not FDA-approved — not the same as Wegovy/Ozempic or Zepbound
RxSpan MD takes this head-to-head with the higher Desk Score, 86/100 (B) against 65/100 (C) for OnlyRx. OnlyRx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
OnlyRx
65/100
C
RxSpan MD
86/100
B
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | OnlyRx | RxSpan MD |
|---|---|---|
| Semaglutide | $179/mo (starting dose, promotional rate, compounded) | From $194/mo |
| Tirzepatide | $249/mo (starting dose, compounded) | $329/mo |
| Coverage | Coverage not published | All 50 states |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Readers who want compounded GLP-1 in oral-tablet and injection with named prescribers. | Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach. |
| Desk Score | 65/100C | 86/100B |
The verdict
Desk pick — RxSpan MDRxSpan MD takes this head-to-head with the higher Desk Score, 86/100 (B) against 65/100 (C) for OnlyRx. OnlyRx still holds its ground where its strengths line up with yours.
Choose OnlyRx if…
Readers who want compounded GLP-1 in oral-tablet and injection with named prescribers.
$179/mo (starting dose, promotional rate, compounded) sema · $249/mo (starting dose, compounded) tirz · Coverage not published
Choose RxSpan MD if…
Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach.
From $194/mo sema · $329/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: OnlyRx · RxSpan MD.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.
More head-to-heads
- OnlyRx vs CoreAge Rx
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- OnlyRx vs Strut Health
- RxSpan MD vs Ondra Health
- OnlyRx vs Invigor Medical
- RxSpan MD vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.