Head-to-head dispatch
LillyDirect Foundayo vs ShedRx
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Eli Lilly's manufacturer direct-pay channel for Foundayo (orforglipron), the first oral GLP-1 pill for weight loss.
Marked down on: Lower mean weight loss vs Wegovy (14.9%) and Zepbound (20.9%) — labeled-dose 11.1% per Foundayo PI
Desk Score
Widest formulation spread in the ranking — injection, liquid drops, lozenges and a daily oral pill, plus a real brand Zepbound lane.
$199/mo sema · $299/mo tirz
Marked down on: The advertised "as low as $239" tirzepatide rate needs a twelve-month commitment — month-to-month is $299
ShedRx takes this head-to-head with the higher Desk Score, 85/100 (B) against 82/100 (B−) for LillyDirect Foundayo. LillyDirect Foundayo still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
LillyDirect Foundayo
82/100
B−
ShedRx
85/100
B
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | LillyDirect Foundayo | ShedRx |
|---|---|---|
| Semaglutide | Not listed on LillyDirect Foundayo's site (checked July 20, 2026) | $199/mo |
| Tirzepatide | Not listed on LillyDirect Foundayo's site (checked July 20, 2026) | $299/mo |
| Coverage | All 50 states | All 50 states |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Patients with commercial insurance who want the cheapest legal brand-name GLP-1. | People who want a needle-free route or a brand-name option without leaving one provider. |
| Desk Score | 82/100B− | 85/100B |
The verdict
Desk pick — ShedRxShedRx takes this head-to-head with the higher Desk Score, 85/100 (B) against 82/100 (B−) for LillyDirect Foundayo. LillyDirect Foundayo still holds its ground where its strengths line up with yours.
Choose LillyDirect Foundayo if…
Patients with commercial insurance who want the cheapest legal brand-name GLP-1.
All 50 states
Choose ShedRx if…
People who want a needle-free route or a brand-name option without leaving one provider.
$199/mo sema · $299/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: LillyDirect Foundayo · ShedRx.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: one price at every dose, both molecules, all 50 states — but the $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs LillyDirect Foundayo
- CoreAge Rx vs ShedRx
- LillyDirect Foundayo vs Vaylen
- ShedRx vs Vaylen
- LillyDirect Foundayo vs Sesame Care
- RxSpan MD vs ShedRx
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.