Head-to-head dispatch
LillyDirect Foundayo vs RxSpan MD
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Eli Lilly's manufacturer direct-pay channel for Foundayo (orforglipron), the first oral GLP-1 pill for weight loss.
Marked down on: Lower mean weight loss vs Wegovy (14.9%) and Zepbound (20.9%) — labeled-dose 11.1% per Foundayo PI
Desk Score
A physician-founded desk with one of the widest menus in the ranking — compounded and brand-name GLP-1 across injectable and oral routes, microdosing, plus longevity, hair, and sexual-health lines — with transparent, all-inclusive pricing across all 50 states.
Marked down on: Compounded semaglutide and tirzepatide are not FDA-approved — not the same as Wegovy/Ozempic or Zepbound
RxSpan MD takes this head-to-head with the higher Desk Score, 86/100 (B) against 82/100 (B−) for LillyDirect Foundayo. LillyDirect Foundayo still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
LillyDirect Foundayo
82/100
B−
RxSpan MD
86/100
B
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | LillyDirect Foundayo | RxSpan MD |
|---|---|---|
| Semaglutide | Not disclosed | From $194/mo |
| Tirzepatide | Not disclosed | $329/mo |
| Coverage | All 50 states | All 50 states |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Patients with commercial insurance who want the cheapest legal brand-name GLP-1. | Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach. |
| Desk Score | 82/100B− | 86/100B |
The verdict
Desk pick — RxSpan MDRxSpan MD takes this head-to-head with the higher Desk Score, 86/100 (B) against 82/100 (B−) for LillyDirect Foundayo. LillyDirect Foundayo still holds its ground where its strengths line up with yours.
Choose LillyDirect Foundayo if…
Patients with commercial insurance who want the cheapest legal brand-name GLP-1.
Not disclosed sema · Not disclosed tirz · All 50 states
Choose RxSpan MD if…
Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach.
From $194/mo sema · $329/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: LillyDirect Foundayo · RxSpan MD.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.
More head-to-heads
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- RxSpan MD vs Ondra Health
- LillyDirect Foundayo vs Invigor Medical
- RxSpan MD vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.