Head-to-head comparison
LillyDirect Foundayo vs RxSpan MD
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Eli Lilly's manufacturer direct-pay channel for Foundayo (orforglipron), the first oral GLP-1 pill for weight loss.
Marked down on: Lower mean weight loss vs Wegovy (14.9%) and Zepbound (20.9%) — labeled-dose 11.1% per Foundayo PI
Desk Score
A physician-founded desk with one of the widest menus in the ranking — compounded and brand-name GLP-1 across injectable and oral routes, microdosing, plus longevity, hair, and sexual-health lines — with transparent, all-inclusive pricing across all 50 states.
$249/mo sema · $329/mo tirz · Verified August 2026
Marked down on: You pay before a clinician reads your intake, and RxSpan MD publishes no refund policy — the word "refund" appears nowhere on the site, and the terms of service say only that you agree to pay all fees. The cheapest advertised rate is a single upfront payment of $2,094 for a year of semaglutide, and the plan card says it auto-renews
RxSpan MD takes this head-to-head with the higher Desk Score, 88/100 (B+) against 82/100 (B−) for LillyDirect Foundayo. LillyDirect Foundayo still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
LillyDirect Foundayo
82/100
B−
RxSpan MD
88/100
B+
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | LillyDirect Foundayo | RxSpan MD |
|---|---|---|
| Semaglutide | Not listed on LillyDirect Foundayo's site (checked July 2026) | $249/mo$249/mo month-to-month (compounded injection; $219/mo on a 3-month plan, $199/mo on 6 months, $175/mo on the 12-month plan billed as one payment of $2,094 up front with the sitewide STARTNOW code); oral capsules $249/mo on the same ladder, as low as $162/mo billed $1,933 up front |
| Tirzepatide | Not listed on LillyDirect Foundayo's site (checked July 2026) | $329/mo$329/mo month-to-month (compounded injection; $243/mo on the 12-month plan billed as one payment of $2,905 up front with the STARTNOW code); oral capsules $349/mo |
| Coverage | All 50 states | All 50 states (varies by provider licensure; no state list published) |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Patients with commercial insurance who want the cheapest legal brand-name GLP-1. | Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach. |
| Desk Score | 82/100B− | 88/100B+ |
The verdict
Desk pick — RxSpan MDRxSpan MD takes this head-to-head with the higher Desk Score, 88/100 (B+) against 82/100 (B−) for LillyDirect Foundayo. LillyDirect Foundayo still holds its ground where its strengths line up with yours.
Choose LillyDirect Foundayo if…
Patients with commercial insurance who want the cheapest legal brand-name GLP-1.
All 50 states
Choose RxSpan MD if…
Patients who want a broad, physician-led menu across GLP-1 routes and adjacent longevity care, with transparent all-inclusive pricing and nationwide reach.
$249/mo sema · $329/mo tirz · All 50 states (varies by provider licensure; no state list published)
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: LillyDirect Foundayo · RxSpan MD.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs LillyDirect Foundayo
- CoreAge Rx vs RxSpan MD
- LillyDirect Foundayo vs Sesame Care
- He & She MD vs RxSpan MD
- LillyDirect Foundayo vs Shed
- Found vs RxSpan MD
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.