Head-to-head comparison
He & She MD vs Wisp
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
He & She MD is a nationwide telehealth weight-loss clinic offering doctor-prescribed GLP-1 medications: compounded semaglutide and tirzepatide (injectable or oral) with brand-name Ozempic and Zepbound alongside, on a published 1/3/6/12-month plan table.
$249/mo sema · $339/mo tirz · Verified August 2026
Marked down on: Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap
Desk Score
Wisp (hellowisp.com) is a large women's telehealth service whose weight care aisle offers brand-name Wegovy, Zepbound and Saxenda written for your own pharmacy, plus compounded sublingual semaglutide drops at $225/month on top of a recurring $99/month consult.
$225/mo (+ membership fee) sema · Verified August 2026
Marked down on: The consult is a separate, recurring $99/month charge that the product card does not show, so the real cost of the sublingual program is $324/mo — well above a compounded injection at most sellers, for the weaker formulation
He & She MD takes this head-to-head with the higher Desk Score, 83/100 (B) against 79/100 (C+) for Wisp. Wisp still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
He & She MD
83/100
B
Wisp
79/100
C+
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | He & She MD | Wisp |
|---|---|---|
| Semaglutide | $249/mo$249/mo month-to-month (the 1-month plan on its product-page table; 3-month $219/mo, 6-month $199/mo, 12-month $99/mo, each a single purchase of the term; the home page's 6-month block is $139/mo promo for the first 6 months, then renews at $1,194 per 6 months; compounded injectable) | $225/mo+ membership fee$225/mo (compounded sublingual drops, 15 mL) plus the separate $99/mo Weight Care Consult — $324/mo all in |
| Tirzepatide | $339/mo$339/mo month-to-month (the 1-month plan on its product-page table; 3-month $309/mo, 6-month $289/mo, 12-month $159/mo, each a single purchase of the term; the home page's 6-month block is $199/mo promo for the first 6 months, then renews at $1,734 per 6 months; compounded injectable) | Not listed on Wisp's site (checked August 2026) |
| Coverage | All states except Louisiana (GLP-1) | 40 states plus DC for the branded injectables (12 of them delivery-only or local-pickup-only); 27 states plus DC for the compounded sublingual semaglutide |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | People who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate. | A woman who wants brand-name Wegovy or Zepbound written by an established clinic and filled on her own insurance — not for anyone shopping compounded injections on price. |
| Desk Score | 83/100B | 79/100C+ |
The verdict
Desk pick — He & She MDHe & She MD takes this head-to-head with the higher Desk Score, 83/100 (B) against 79/100 (C+) for Wisp. Wisp still holds its ground where its strengths line up with yours.
Choose He & She MD if…
People who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate.
$249/mo sema · $339/mo tirz · All states except Louisiana (GLP-1)
Choose Wisp if…
A woman who wants brand-name Wegovy or Zepbound written by an established clinic and filled on her own insurance — not for anyone shopping compounded injections on price.
$225/mo (+ membership fee) sema · 40 states plus DC for the branded injectables (12 of them delivery-only or local-pickup-only); 27 states plus DC for the compounded sublingual semaglutide
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: He & She MD · Wisp.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs He & She MD
- CoreAge Rx vs Wisp
- He & She MD vs RxSpan MD
- RxSpan MD vs Wisp
- Found vs He & She MD
- Shed vs Wisp
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.