Head-to-head dispatch
He & She MD vs ShedRx
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
He & She MD is a nationwide telehealth weight-loss clinic offering doctor-prescribed GLP-1 medications: compounded semaglutide and tirzepatide (injectable or oral), with brand-name…
Marked down on: Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap
Desk Score
Widest formulation spread in the ranking — injection, liquid drops, lozenges and a daily oral pill, plus a real brand Zepbound lane.
Marked down on: The advertised "as low as $239" tirzepatide rate needs a twelve-month commitment — month-to-month is $299
ShedRx takes this head-to-head with the higher Desk Score, 85/100 (B) against 83/100 (B) for He & She MD. He & She MD still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
He & She MD
83/100
B
ShedRx
85/100
B
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | He & She MD | ShedRx |
|---|---|---|
| Semaglutide | $199/mo (month to month, compounded; every lower rate is a prepaid term) | $199/mo |
| Tirzepatide | $299/mo (month to month, compounded; every lower rate is a prepaid term) | $299/mo |
| Coverage | All states except Louisiana (GLP-1) | All 50 states |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Readers who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate. | People who want a needle-free route or a brand-name option without leaving one provider. |
| Desk Score | 83/100B | 85/100B |
The verdict
Desk pick — ShedRxShedRx takes this head-to-head with the higher Desk Score, 85/100 (B) against 83/100 (B) for He & She MD. He & She MD still holds its ground where its strengths line up with yours.
Choose He & She MD if…
Readers who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate.
$199/mo (month to month, compounded; every lower rate is a prepaid term) sema · $299/mo (month to month, compounded; every lower rate is a prepaid term) tirz · All states except Louisiana (GLP-1)
Choose ShedRx if…
People who want a needle-free route or a brand-name option without leaving one provider.
$199/mo sema · $299/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: He & She MD · ShedRx.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.
More head-to-heads
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- He & She MD vs Invigor Medical
- ShedRx vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.