Head-to-head comparison
Enhance MD vs Luma Meds
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
The clearest tiered compounded pricing in the ranking — separate lines for sema, tirzepatide, a microdose tier, and a sema+tirz combo — with lab testing built in.
$249 per 4 weeks sema · $329 per 4 weeks tirz · Verified August 2026
Marked down on: Compounded only — not FDA-approved
Desk Score
Fully online compounded GLP-1 telehealth offering semaglutide and tirzepatide injections from FDA-regulated 503A and 503B compounding pharmacies.
$249/mo sema · $299/mo tirz · Verified July 2026
Marked down on: Compounding pharmacy partner not publicly named
Enhance MD takes this head-to-head with the higher Desk Score, 79/100 (C+) against 64/100 (C) for Luma Meds. Luma Meds still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Enhance MD
79/100
C+
Luma Meds
64/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Enhance MD | Luma Meds |
|---|---|---|
| Semaglutide | $249 per 4 weeks$249 every 4 weeks month-to-month (13 charges a year); $237/mo billed every 12 weeks, $224/mo billed every 24 weeks, $212/mo only on the 12-month prepay billed every 48 weeks | $249/mo$249/mo (compounded) |
| Tirzepatide | $329 per 4 weeks$329 every 4 weeks month-to-month (13 charges a year); $313/mo billed every 12 weeks, $296/mo billed every 24 weeks, $280/mo only on the 12-month prepay billed every 48 weeks | $299/mo$299/mo (compounded) |
| Coverage | 40 states + DC (the FAQ names them; AL, AR, GA, HI, LA, MS, MO, ND, SC and TN are not served) | Not listed on Luma Meds's site (checked July 2026) |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Patients who want fully itemized compounded options and ongoing metabolic oversight, and don't need brand-name or oral routes. | People who want a LegitScript-certified compounded GLP-1 plan with free shipping and provider support. |
| Desk Score | 79/100C+ | 64/100C |
The verdict
Desk pick — Enhance MDEnhance MD takes this head-to-head with the higher Desk Score, 79/100 (C+) against 64/100 (C) for Luma Meds. Luma Meds still holds its ground where its strengths line up with yours.
Choose Enhance MD if…
Patients who want fully itemized compounded options and ongoing metabolic oversight, and don't need brand-name or oral routes.
$249 per 4 weeks sema · $329 per 4 weeks tirz · 40 states + DC (the FAQ names them; AL, AR, GA, HI, LA, MS, MO, ND, SC and TN are not served)
Choose Luma Meds if…
People who want a LegitScript-certified compounded GLP-1 plan with free shipping and provider support.
$249/mo sema · $299/mo tirz
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Enhance MD · Luma Meds.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs Enhance MD
- CoreAge Rx vs Luma Meds
- Enhance MD vs Peak Wellness
- Luma Meds vs Peak Wellness
- EdgeRx vs Enhance MD
- Independent Wellness vs Luma Meds
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.