Head-to-head comparison
1st Optimal vs Tyde Wellness
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets.
Marked down on: No public monthly pricing disclosed
Desk Score
Compounded semaglutide from $149 a month and tirzepatide from $249, sold as a membership with nutrition coaching, a free consultation, and five named pharmacies — but no published dose ladder.
From $149/mo sema · From $249/mo tirz · Verified August 2026
Marked down on: No brand-name access
Tyde Wellness takes this head-to-head with the higher Desk Score, 90/100 (A−) against 46/100 (C) for 1st Optimal. 1st Optimal still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
1st Optimal
46/100
C
Tyde Wellness
90/100
A−
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | 1st Optimal | Tyde Wellness |
|---|---|---|
| Semaglutide | Not listed on 1st Optimal's site (checked July 2026) | From $149/moFrom $149/mo, billed as a recurring membership (monthly or every 4 weeks); no dose ladder published; compounded injectable |
| Tirzepatide | Not listed on 1st Optimal's site (checked July 2026) | From $249/moFrom $249/mo, billed as a recurring membership (monthly or every 4 weeks); no dose ladder published; compounded injectable |
| Coverage | Not listed on 1st Optimal's site (checked July 2026) | All 50 states |
| Brand-name | Compounded only | Compounded only |
| Oral option | Yes | Injectable only |
| Best for | Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. | Someone who wants coaching and a clinician visit bundled with the prescription, and who will confirm the real monthly figure on the consult before enrolling. |
| Desk Score | 46/100C | 90/100A− |
The verdict
Desk pick — Tyde WellnessTyde Wellness takes this head-to-head with the higher Desk Score, 90/100 (A−) against 46/100 (C) for 1st Optimal. 1st Optimal still holds its ground where its strengths line up with yours.
Choose 1st Optimal if…
Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Tyde Wellness if…
Someone who wants coaching and a clinician visit bundled with the prescription, and who will confirm the real monthly figure on the consult before enrolling.
From $149/mo sema · From $249/mo tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: 1st Optimal · Tyde Wellness.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
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Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.