Head-to-head comparison
Nucore Health vs Vyora Wellness
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Nucore Health is a physician-owned, LegitScript-certified telehealth platform serving all 50 states, focused on GLP-1 and longevity care.
From $299/mo (lowest dose rung) sema · From $199/mo (lowest dose rung) tirz · Verified June 2026
Marked down on: Published pricing is gated behind the intake quiz — no upfront cost shown
Desk Score
Vyora Wellness offers compounded semaglutide ($299/mo) and compounded tirzepatide ($399/mo) as 4-week subscription plans.
$299/mo sema · $399/mo tirz · Verified July 2026
Marked down on: State availability not publicly disclosed
Nucore Health takes this head-to-head with the higher Desk Score, 65/100 (C) against 56/100 (C) for Vyora Wellness. Vyora Wellness still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Nucore Health
65/100
C
Vyora Wellness
56/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Nucore Health | Vyora Wellness |
|---|---|---|
| Semaglutide | From $299/molowest dose rung$299/mo (starting dose, compounded) | $299/mo$299/mo (compounded) |
| Tirzepatide | From $199/molowest dose rung$199/mo (microdose tier, compounded) | $399/mo$399/mo (compounded) |
| Coverage | Not listed on Nucore Health's site (checked June 2026) | Not listed on Vyora Wellness's site (checked July 2026) |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Longevity-minded patients wanting microdose GLP-1, NAD+ and sermorelin from a LegitScript-certified clinic. | Patients wanting coaching-inclusive compounded GLP-1 programs. |
| Desk Score | 65/100C | 56/100C |
The verdict
Desk pick — Nucore HealthNucore Health takes this head-to-head with the higher Desk Score, 65/100 (C) against 56/100 (C) for Vyora Wellness. Vyora Wellness still holds its ground where its strengths line up with yours.
Choose Nucore Health if…
Longevity-minded patients wanting microdose GLP-1, NAD+ and sermorelin from a LegitScript-certified clinic.
From $299/mo (lowest dose rung) sema · From $199/mo (lowest dose rung) tirz
Choose Vyora Wellness if…
Patients wanting coaching-inclusive compounded GLP-1 programs.
$299/mo sema · $399/mo tirz
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Nucore Health · Vyora Wellness.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
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Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.