Head-to-head comparison
Independent Wellness vs Onyx Weight Loss
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Telehealth wellness clinic offering GLP-1 medications on a 4-week billing cycle.
$249/mo sema · $379/mo tirz · Verified July 2026
Marked down on: Limited public information on program details
Desk Score
Onyx Weight Loss is a nurse-practitioner-led telehealth clinic based in Mooresville, NC, offering GLP-1 and GLP-1/GIP weight-loss medications alongside peptides and HRT across 8 states.
From $228/mo (lowest dose rung) sema · From $280/mo (lowest dose rung) tirz · Verified July 2026
Marked down on: Only 8 states (NC, CO, ME, VT, VA, IA, NH, PA) — excludes the majority of the US
Independent Wellness takes this head-to-head with the higher Desk Score, 80/100 (B−) against 62/100 (C) for Onyx Weight Loss. Onyx Weight Loss still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Independent Wellness
80/100
B−
Onyx Weight Loss
62/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Independent Wellness | Onyx Weight Loss |
|---|---|---|
| Semaglutide | $249/mo$249/mo (all doses, compounded) | From $228/molowest dose rung$228/mo (starting dose, compounded) |
| Tirzepatide | $379/mo$379/mo (all doses, compounded) | From $280/molowest dose rung$280/mo (starting dose, compounded) |
| Coverage | All 50 states | 8 states |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Mainstream telehealth GLP-1 access. | NP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl. |
| Desk Score | 80/100B− | 62/100C |
The verdict
Desk pick — Independent WellnessIndependent Wellness takes this head-to-head with the higher Desk Score, 80/100 (B−) against 62/100 (C) for Onyx Weight Loss. Onyx Weight Loss still holds its ground where its strengths line up with yours.
Choose Independent Wellness if…
Mainstream telehealth GLP-1 access.
$249/mo sema · $379/mo tirz · All 50 states
Choose Onyx Weight Loss if…
NP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl.
From $228/mo (lowest dose rung) sema · From $280/mo (lowest dose rung) tirz · 8 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Independent Wellness · Onyx Weight Loss.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs Independent Wellness
- CoreAge Rx vs Onyx Weight Loss
- Independent Wellness vs Invigor Medical
- Invigor Medical vs Onyx Weight Loss
- Enhance MD vs Independent Wellness
- Onyx Weight Loss vs Peak Wellness
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.