Head-to-head dispatch
He & She MD vs Layla
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
He & She MD is a nationwide telehealth weight-loss clinic offering doctor-prescribed GLP-1 medications: compounded semaglutide and tirzepatide (injectable or oral) with brand-name Ozempic and Zepbound alongside, on a published 1/3/6/12-month plan table.
$249/mo month-to-month (the 1-month plan on its product-page table; 3-month $219/mo, 6-month $199/mo, 12-month $99/mo, each a single purchase of the term; the home page's 6-month block is $139/mo promo for the first 6 months, then renews at $1,194 per 6 months; compounded injectable) sema · $339/mo month-to-month (the 1-month plan on its product-page table; 3-month $309/mo, 6-month $289/mo, 12-month $159/mo, each a single purchase of the term; the home page's 6-month block is $199/mo promo for the first 6 months, then renews at $1,734 per 6 months; compounded injectable) tirz · Verified August 29, 2026
Marked down on: Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap
Desk Score
Layla is a US telehealth weight-loss program built around semaglutide, offering compounded semaglutide as injections and as oral dropper drops.
$237/mo (all doses, compounded) sema · $199/mo (all doses, compounded) tirz · Verified July 16, 2026
Marked down on: Brand-inclusive GLP-1 program is expensive, starting around 1,299 dollars
He & She MD takes this head-to-head with the higher Desk Score, 83/100 (B) against 70/100 (C) for Layla. Layla still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
He & She MD
83/100
B
Layla
70/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | He & She MD | Layla |
|---|---|---|
| Semaglutide | $249/mo month-to-month (the 1-month plan on its product-page table; 3-month $219/mo, 6-month $199/mo, 12-month $99/mo, each a single purchase of the term; the home page's 6-month block is $139/mo promo for the first 6 months, then renews at $1,194 per 6 months; compounded injectable) | $237/mo (all doses, compounded) |
| Tirzepatide | $339/mo month-to-month (the 1-month plan on its product-page table; 3-month $309/mo, 6-month $289/mo, 12-month $159/mo, each a single purchase of the term; the home page's 6-month block is $199/mo promo for the first 6 months, then renews at $1,734 per 6 months; compounded injectable) | $199/mo (all doses, compounded) |
| Coverage | All states except Louisiana (GLP-1) | Not listed on Layla's site (checked July 16, 2026) |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | People who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate. | People wanting oral or injectable semaglutide with a brand-inclusive glp-1 upgrade path. |
| Desk Score | 83/100B | 70/100C |
The verdict
Desk pick — He & She MDHe & She MD takes this head-to-head with the higher Desk Score, 83/100 (B) against 70/100 (C) for Layla. Layla still holds its ground where its strengths line up with yours.
Choose He & She MD if…
People who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate.
$249/mo month-to-month (the 1-month plan on its product-page table; 3-month $219/mo, 6-month $199/mo, 12-month $99/mo, each a single purchase of the term; the home page's 6-month block is $139/mo promo for the first 6 months, then renews at $1,194 per 6 months; compounded injectable) sema · $339/mo month-to-month (the 1-month plan on its product-page table; 3-month $309/mo, 6-month $289/mo, 12-month $159/mo, each a single purchase of the term; the home page's 6-month block is $199/mo promo for the first 6 months, then renews at $1,734 per 6 months; compounded injectable) tirz · All states except Louisiana (GLP-1)
Choose Layla if…
People wanting oral or injectable semaglutide with a brand-inclusive glp-1 upgrade path.
$237/mo (all doses, compounded) sema · $199/mo (all doses, compounded) tirz
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: He & She MD · Layla.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: one price at every dose, both molecules, all 50 states — but the $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs He & She MD
- CoreAge Rx vs Layla
- He & She MD vs Semaglutide Online
- Layla vs Tyde Wellness
- Found vs He & She MD
- Layla vs Semaglutide Online
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.