Head-to-head comparison
Fifty 410 vs Jyra Health
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Fifty 410 is a direct-to-consumer weight-loss telehealth service offering personalized compounded semaglutide and tirzepatide prescribed by licensed providers and prepared by FDA-registered 503A and 503B.
$99/mo sema · From $133/mo (lowest dose rung) tirz · Verified July 2026
Marked down on: Does not bill insurance directly
FDAWarning letter issued to Aspen Aesthetics dba Fifty 410 in February 2026. See the FDA warning-letter database.
Desk Score
Jyra Health is an online weight-loss and longevity telehealth clinic offering compounded GLP-1 — semaglutide from $99/mo and tirzepatide from $133/mo (limited time).
From $99/mo (lowest dose rung) sema · $133/mo (promo rate) tirz · Verified June 2026
Marked down on: The $133/mo tirzepatide price is flagged 'limited time' — verify current pricing before enrolling
Jyra Health takes this head-to-head with the higher Desk Score, 75/100 (C) against 62/100 (C) for Fifty 410. Fifty 410 still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Fifty 410
62/100
C
Jyra Health
75/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Fifty 410 | Jyra Health |
|---|---|---|
| Semaglutide | $99/mo$99/mo (all doses, compounded) | From $99/molowest dose rung$99/mo (starting dose, plus a separate fee, compounded) |
| Tirzepatide | From $133/molowest dose rung$133/mo (starting dose, compounded) | $133/mopromo rate$133/mo (starting dose, promotional rate, compounded) |
| Coverage | Not listed on Fifty 410's site (checked July 2026) | All 50 states |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Budget-focused buyers wanting transparent no-membership compounded GLP-1 pricing. | Budget shoppers wanting very low-cost compounded semaglutide or tirzepatide in any state. |
| Desk Score | 62/100C | 75/100C |
The verdict
Desk pick — Jyra HealthJyra Health takes this head-to-head with the higher Desk Score, 75/100 (C) against 62/100 (C) for Fifty 410. Fifty 410 still holds its ground where its strengths line up with yours.
Choose Fifty 410 if…
Budget-focused buyers wanting transparent no-membership compounded GLP-1 pricing.
$99/mo sema · From $133/mo (lowest dose rung) tirz
FDAWarning letter issued to Aspen Aesthetics dba Fifty 410 in February 2026. See the FDA warning-letter database.
Choose Jyra Health if…
Budget shoppers wanting very low-cost compounded semaglutide or tirzepatide in any state.
From $99/mo (lowest dose rung) sema · $133/mo (promo rate) tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Fifty 410 · Jyra Health.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs Fifty 410
- CoreAge Rx vs Jyra Health
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- Jyra Health vs Sunlight
- Fifty 410 vs NewSelf
- Jyra Health vs NewSelf
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.