Head-to-head comparison
EdgeRx vs Onyx Weight Loss
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
A men's-only protocol shop with flat, disclosed GLP-1 pricing, a named Chief Medical Advisor, and a named 503A compounding pharmacy — rare transparency for this tier of the ranking.
$229/mo sema · $299/mo tirz · Verified August 2026
Marked down on: Men-only — not built for or marketed to women or other readers
Desk Score
Onyx Weight Loss is a nurse-practitioner-led telehealth clinic based in Mooresville, NC, offering GLP-1 and GLP-1/GIP weight-loss medications alongside peptides and HRT across 8 states.
From $228/mo (lowest dose rung) sema · From $280/mo (lowest dose rung) tirz · Verified July 2026
Marked down on: Only 8 states (NC, CO, ME, VT, VA, IA, NH, PA) — excludes the majority of the US
EdgeRx takes this head-to-head with the higher Desk Score, 81/100 (B−) against 62/100 (C) for Onyx Weight Loss. Onyx Weight Loss still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
EdgeRx
81/100
B−
Onyx Weight Loss
62/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | EdgeRx | Onyx Weight Loss |
|---|---|---|
| Semaglutide | $229/mo$229/mo injectable | From $228/molowest dose rung$228/mo (starting dose, compounded) |
| Tirzepatide | $299/mo$299/mo injectable | From $280/molowest dose rung$280/mo (starting dose, compounded) |
| Coverage | 46 states (excludes Arkansas, Indiana, Minnesota, South Carolina) | 8 states |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Men who want a straightforward, disclosed weekly-injectable price on either molecule and value knowing the pharmacy by name. | NP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl. |
| Desk Score | 81/100B− | 62/100C |
The verdict
Desk pick — EdgeRxEdgeRx takes this head-to-head with the higher Desk Score, 81/100 (B−) against 62/100 (C) for Onyx Weight Loss. Onyx Weight Loss still holds its ground where its strengths line up with yours.
Choose EdgeRx if…
Men who want a straightforward, disclosed weekly-injectable price on either molecule and value knowing the pharmacy by name.
$229/mo sema · $299/mo tirz · 46 states (excludes Arkansas, Indiana, Minnesota, South Carolina)
Choose Onyx Weight Loss if…
NP-led GLP-1 telehealth across 8 states; sema from $228/mo or tirz from $280/mo, med+ship incl.
From $228/mo (lowest dose rung) sema · From $280/mo (lowest dose rung) tirz · 8 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: EdgeRx · Onyx Weight Loss.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs EdgeRx
- CoreAge Rx vs Onyx Weight Loss
- EdgeRx vs Invigor Medical
- Invigor Medical vs Onyx Weight Loss
- EdgeRx vs Enhance MD
- Onyx Weight Loss vs Peak Wellness
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.