Head-to-head dispatch
Cost Plus Drugs vs Tryozi
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Mark Cuban's transparent-pricing online pharmacy.
$279/mo (brand Ozempic) sema · Verified July 20, 2026
Marked down on: Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
Desk Score
Florida telehealth selling compounded GLP-1 injections at a flat price that does not rise with dose, naming all four of its 503A compounding pharmacies.
$279/mo (compounded) sema · $379/mo (compounded) tirz · Verified July 30, 2026
Marked down on: Headline $139 is a first-month half-price offer; the ongoing rate is $279
Tryozi takes this head-to-head with the higher Desk Score, 81/100 (B−) against 71/100 (C) for Cost Plus Drugs. Cost Plus Drugs still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Cost Plus Drugs
71/100
C
Tryozi
81/100
B−
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Cost Plus Drugs | Tryozi |
|---|---|---|
| Semaglutide | $279/mo (brand Ozempic) | $279/mo (compounded) |
| Tirzepatide | Not listed on Cost Plus Drugs's site (checked July 20, 2026) | $379/mo (compounded) |
| Coverage | All 50 states | All 50 states |
| Brand-name | Yes | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | The cheapest transparent-pricing brand-name Ozempic channel. | Shoppers who want the pharmacy named and a price that does not climb with dose. |
| Desk Score | 71/100C | 81/100B− |
The verdict
Desk pick — TryoziTryozi takes this head-to-head with the higher Desk Score, 81/100 (B−) against 71/100 (C) for Cost Plus Drugs. Cost Plus Drugs still holds its ground where its strengths line up with yours.
Choose Cost Plus Drugs if…
The cheapest transparent-pricing brand-name Ozempic channel.
$279/mo (brand Ozempic) sema · All 50 states
Choose Tryozi if…
Shoppers who want the pharmacy named and a price that does not climb with dose.
$279/mo (compounded) sema · $379/mo (compounded) tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: Cost Plus Drugs · Tryozi.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: one price at every dose, both molecules, all 50 states — but the $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs Cost Plus Drugs
- CoreAge Rx vs Tryozi
- Cost Plus Drugs vs Sprout Health
- Enhance MD vs Tryozi
- Better U Care vs Cost Plus Drugs
- Peak Wellness vs Tryozi
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.