Head-to-head comparison
CLYR Health vs He & She MD
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
CLYR Health is a Florida-based telehealth pharmacy offering compounded GLP-1 weight-loss injections alongside sexual-health, longevity and wellness treatments.
$229/mo sema · $249/mo tirz · Verified July 2026
Marked down on: State availability gated behind intake; not published on the marketing site
Desk Score
He & She MD is a nationwide telehealth weight-loss clinic offering doctor-prescribed GLP-1 medications: compounded semaglutide and tirzepatide (injectable or oral) with brand-name Ozempic and Zepbound alongside, on a published 1/3/6/12-month plan table.
$249/mo sema · $339/mo tirz · Verified August 2026
Marked down on: Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap
He & She MD takes this head-to-head with the higher Desk Score, 83/100 (B) against 68/100 (C) for CLYR Health. CLYR Health still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
CLYR Health
68/100
C
He & She MD
83/100
B
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | CLYR Health | He & She MD |
|---|---|---|
| Semaglutide | $229/mo$229/mo (compounded) | $249/mo$249/mo month-to-month (the 1-month plan on its product-page table; 3-month $219/mo, 6-month $199/mo, 12-month $99/mo, each a single purchase of the term; the home page's 6-month block is $139/mo promo for the first 6 months, then renews at $1,194 per 6 months; compounded injectable) |
| Tirzepatide | $249/mo$249/mo (compounded) | $339/mo$339/mo month-to-month (the 1-month plan on its product-page table; 3-month $309/mo, 6-month $289/mo, 12-month $159/mo, each a single purchase of the term; the home page's 6-month block is $199/mo promo for the first 6 months, then renews at $1,734 per 6 months; compounded injectable) |
| Coverage | Not listed on CLYR Health's site (checked July 2026) | All states except Louisiana (GLP-1) |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Flat-rate compounded GLP-1 with pricing that does not increase as your dose goes up. | People who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate. |
| Desk Score | 68/100C | 83/100B |
The verdict
Desk pick — He & She MDHe & She MD takes this head-to-head with the higher Desk Score, 83/100 (B) against 68/100 (C) for CLYR Health. CLYR Health still holds its ground where its strengths line up with yours.
Choose CLYR Health if…
Flat-rate compounded GLP-1 with pricing that does not increase as your dose goes up.
$229/mo sema · $249/mo tirz
Choose He & She MD if…
People who want a published GLP-1 price ladder, injectable or oral, and are willing to prepay a term to reach the low rate.
$249/mo sema · $339/mo tirz · All states except Louisiana (GLP-1)
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: CLYR Health · He & She MD.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CLYR Health vs CoreAge Rx
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- CLYR Health vs Shed
- Found vs He & She MD
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.