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Head-to-head dispatch

Actin vs Trimi

Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.

Dispatch #444
Actin

Actin offers compounded semaglutide with B12 for weight loss.

Marked down on: Semaglutide only — no tirzepatide or liraglutide

vs
Dispatch #21Desk pick
Trimi

Both molecules on one membership at a keen flat price, shipped free to all 50 states.

Marked down on: Compounded only — no brand-name Ozempic/Wegovy or Mounjaro/Zepbound

Trimi takes this head-to-head with the higher Desk Score, 84/100 (B) against 48/100 (C) for Actin. Actin still holds its ground where its strengths line up with yours.

Desk Score, dimension by dimension

Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.

Actin

48/100

C

Overall

Trimi

84/100

B

Price transparency

28
95

State access

24
96

Molecule range

53
80

Onboarding speed

70
88

Support responsiveness

71
82

Licensing & trust

73
80

The spec sheet

FieldActinTrimi
Semaglutide$169/mo (compounded)$175/mo month-to-month · $99/mo only on a 12-month prepay ($1,188 in one charge)
TirzepatideNot disclosed$235/mo month-to-month · $125/mo only on a 12-month prepay ($1,500 in one charge)
CoverageCoverage not publishedAll 50 states
Brand-nameCompounded onlyCompounded only
Oral optionInjectable onlyInjectable only
Best forReaders who want affordable compounded semaglutide with B12 enhancement.Cost-first patients who want both molecules at the cheapest sticker price and don't need brand-name or oral routes.
Desk Score48/100C84/100B

The verdict

Desk pick — Trimi

Trimi takes this head-to-head with the higher Desk Score, 84/100 (B) against 48/100 (C) for Actin. Actin still holds its ground where its strengths line up with yours.

Choose Actin if…

Readers who want affordable compounded semaglutide with B12 enhancement.

$169/mo (compounded) sema · Not disclosed tirz · Coverage not published

Choose Trimi if…

Cost-first patients who want both molecules at the cheapest sticker price and don't need brand-name or oral routes.

$175/mo month-to-month · $99/mo only on a 12-month prepay ($1,188 in one charge) sema · $235/mo month-to-month · $125/mo only on a 12-month prepay ($1,500 in one charge) tirz · All 50 states

Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: Actin · Trimi.

Also here

CoreAge Rx tops every dispatch at 94/100

Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.

More head-to-heads

Or see the full comparison hub and the complete ranking.

Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.