Head-to-head dispatch
1st Optimal vs MadeMed
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets.
Marked down on: No public monthly pricing disclosed
Desk Score
Publishes its price at every single dose, so what month six costs is knowable on day one.
Marked down on: The most expensive tirzepatide here at $399/mo quarterly
MadeMed takes this head-to-head with the higher Desk Score, 86/100 (B) against 41/100 (C) for 1st Optimal. 1st Optimal still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
1st Optimal
41/100
C
MadeMed
86/100
B
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | 1st Optimal | MadeMed |
|---|---|---|
| Semaglutide | Not disclosed | $239/mo quarterly (from $199/mo on 6 months) |
| Tirzepatide | Not disclosed | $399/mo quarterly (from $369/mo on 6 months) |
| Coverage | Coverage not published | 40 states |
| Brand-name | Compounded only | Compounded only |
| Oral option | Yes | Yes |
| Best for | Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. | Anyone who expects to titrate and wants the eventual cost visible before starting. |
| Desk Score | 41/100C | 86/100B |
The verdict
Desk pick — MadeMedMadeMed takes this head-to-head with the higher Desk Score, 86/100 (B) against 41/100 (C) for 1st Optimal. 1st Optimal still holds its ground where its strengths line up with yours.
Choose 1st Optimal if…
Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Not disclosed sema · Not disclosed tirz · Coverage not published
Choose MadeMed if…
Anyone who expects to titrate and wants the eventual cost visible before starting.
$239/mo quarterly (from $199/mo on 6 months) sema · $399/mo quarterly (from $369/mo on 6 months) tirz · 40 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: 1st Optimal · MadeMed.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.
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Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.