Head-to-head comparison
Optimized Health vs SkyRx
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Verified and oral-capable, but availability is limited to five states — a narrow-reach specialist.
$200/mo sema · $250/mo tirz
Marked down on: Only five states served
Desk Score
SkyRx (sky-rx.co) is a US telehealth weight-loss program offering compounded semaglutide as an injection or oral drops, with compounded tirzepatide listed as coming soon.
$199/mo (12-month prepay) sema · Verified July 2026
Marked down on: 199 dollars pricing requires a 12-month subscription paid upfront
Optimized Health takes this head-to-head with the higher Desk Score, 79/100 (C+) against 63/100 (C) for SkyRx. SkyRx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Optimized Health
79/100
C+
SkyRx
63/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Optimized Health | SkyRx |
|---|---|---|
| Semaglutide | $200/mo$200/mo | $199/mo12-month prepay$199/mo (all doses, 12-month plan, compounded) |
| Tirzepatide | $250/mo$250/mo | Not listed on SkyRx's site (checked July 2026) |
| Coverage | MO, IA, KS, UT, WA | Not listed on SkyRx's site (checked July 2026) |
| Brand-name | Compounded only | Compounded only |
| Oral option | Yes | Yes |
| Best for | Patients in MO, IA, KS, UT, or WA who want a verified, oral-capable program. | Shoppers wanting all-inclusive compounded semaglutide with supplies included. |
| Desk Score | 79/100C+ | 63/100C |
The verdict
Desk pick — Optimized HealthOptimized Health takes this head-to-head with the higher Desk Score, 79/100 (C+) against 63/100 (C) for SkyRx. SkyRx still holds its ground where its strengths line up with yours.
Choose Optimized Health if…
Patients in MO, IA, KS, UT, or WA who want a verified, oral-capable program.
$200/mo sema · $250/mo tirz · MO, IA, KS, UT, WA
Choose SkyRx if…
Shoppers wanting all-inclusive compounded semaglutide with supplies included.
$199/mo (12-month prepay) sema
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Optimized Health · SkyRx.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs Optimized Health
- CoreAge Rx vs SkyRx
- Ondra Health vs Optimized Health
- Curex vs SkyRx
- Curex vs Optimized Health
- Fitish vs SkyRx
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.