Head-to-head dispatch
NewSelf vs Primary Clinic (Direct GLP)
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo).
Marked down on: Not available in Mississippi and Louisiana
FDAWarning letter issued to NewSelf Limited dba NewSelf in February 2026. See the FDA warning-letter database.
Desk Score
A Direct Primary Care membership rather than a GLP-1 storefront: the dose-band prices sit on top of an $89/mo membership the FAQ says does not include the drug.
Marked down on: The medication price is on top of an $89/mo membership the FAQ says excludes the drug — all-in is about $174 and $222
Primary Clinic (Direct GLP) takes this head-to-head with the higher Desk Score, 80/100 (B−) against 79/100 (C+) for NewSelf. NewSelf still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
NewSelf
79/100
C+
Primary Clinic (Direct GLP)
80/100
B−
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | NewSelf | Primary Clinic (Direct GLP) |
|---|---|---|
| Semaglutide | $100/mo (compounded) | $85/mo (0.25-0.75 mg band, membership required, compounded) |
| Tirzepatide | $144/mo (compounded) | $133/mo (1.25-2.5 mg band, membership required, compounded) |
| Coverage | 49 states | WA, NM, AZ, UT, FL, DC, KS, OK, VA, GA |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Readers who want lowest-cost compounded GLP-1 with pharmacy quality transparency. | Patients in a covered state who want primary care bundled with the prescription and will price the membership in. |
| Desk Score | 79/100C+ | 80/100B− |
The verdict
Desk pick — Primary Clinic (Direct GLP)Primary Clinic (Direct GLP) takes this head-to-head with the higher Desk Score, 80/100 (B−) against 79/100 (C+) for NewSelf. NewSelf still holds its ground where its strengths line up with yours.
Choose NewSelf if…
Readers who want lowest-cost compounded GLP-1 with pharmacy quality transparency.
$100/mo (compounded) sema · $144/mo (compounded) tirz · 49 states
FDAWarning letter issued to NewSelf Limited dba NewSelf in February 2026. See the FDA warning-letter database.
Choose Primary Clinic (Direct GLP) if…
Patients in a covered state who want primary care bundled with the prescription and will price the membership in.
$85/mo (0.25-0.75 mg band, membership required, compounded) sema · $133/mo (1.25-2.5 mg band, membership required, compounded) tirz · WA, NM, AZ, UT, FL, DC, KS, OK, VA, GA
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: NewSelf · Primary Clinic (Direct GLP).
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: flat all-in pricing, both molecules, all 50 states — no teaser-rate traps.
More head-to-heads
- NewSelf vs CoreAge Rx
- Primary Clinic (Direct GLP) vs Vaylen
- NewSelf vs Strut Health
- Primary Clinic (Direct GLP) vs Ondra Health
- NewSelf vs Invigor Medical
- Primary Clinic (Direct GLP) vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.