Head-to-head comparison
MedLeanRx vs PCOS Sisters
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
MedLeanRx is a physician-guided telehealth weight-loss clinic serving Texas only, based in Spring, TX.
$149/mo (promo rate) sema · From $269/mo (lowest dose rung) tirz · Verified July 2026
Marked down on: Texas only — not available in the other 49 states
Desk Score
PCOS Sisters is a women's telehealth clinic focused on polycystic ovary syndrome that offers a GLP-1 weight and metabolic management program for 150 dollars per month with membership required.
$150/mo (+ membership fee) sema · $150/mo (+ membership fee) tirz · Verified July 2026
Marked down on: Only 12 states served
PCOS Sisters takes this head-to-head with the higher Desk Score, 71/100 (C) against 69/100 (C) for MedLeanRx. MedLeanRx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
MedLeanRx
69/100
C
PCOS Sisters
71/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | MedLeanRx | PCOS Sisters |
|---|---|---|
| Semaglutide | $149/mopromo rate$149/mo (starting dose, promotional rate, compounded) | $150/mo+ membership fee$150/mo (plus a separate fee, compounded) |
| Tirzepatide | From $269/molowest dose rung$269/mo (starting dose, compounded) | $150/mo+ membership fee$150/mo (plus a separate fee, compounded) |
| Coverage | 1 state | 12 states |
| Brand-name | Yes | Yes |
| Oral option | Yes | Yes |
| Best for | Texas-only compounded semaglutide at $149/mo with a brand Wegovy and Zepbound pathway. | Women with pcos seeking glp-1 weight and metabolic care. |
| Desk Score | 69/100C | 71/100C |
The verdict
Desk pick — PCOS SistersPCOS Sisters takes this head-to-head with the higher Desk Score, 71/100 (C) against 69/100 (C) for MedLeanRx. MedLeanRx still holds its ground where its strengths line up with yours.
Choose MedLeanRx if…
Texas-only compounded semaglutide at $149/mo with a brand Wegovy and Zepbound pathway.
$149/mo (promo rate) sema · From $269/mo (lowest dose rung) tirz · 1 state
Choose PCOS Sisters if…
Women with pcos seeking glp-1 weight and metabolic care.
$150/mo (+ membership fee) sema · $150/mo (+ membership fee) tirz · 12 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: MedLeanRx · PCOS Sisters.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- CoreAge Rx vs MedLeanRx
- CoreAge Rx vs PCOS Sisters
- MedLeanRx vs Sesame Care
- PCOS Sisters vs Sesame Care
- MedLeanRx vs Vaylen
- PCOS Sisters vs Vaylen
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.