Head-to-head dispatch
Lyfe Rx vs Medsol RX
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Lyfe Rx offers compounded semaglutide ($289) and compounded tirzepatide ($399).
$225/mo (compounded) sema · $299/mo (compounded) tirz · Verified July 20, 2026
Marked down on: No visible LegitScript or PCAB accreditation
FDAWarning letter issued to Lyfe Rx in September 2025. See the FDA warning-letter database.
Desk Score
Medsol RX is a GLP-1 weight-loss telehealth program offering compounded semaglutide (from $209/mo) and tirzepatide, prescribed by board-certified clinicians via OpenLoop and shipped nationwide.
$209/mo (compounded) sema · $250/mo (compounded) tirz · Verified June 18, 2026
Marked down on: Doesn't name its compounding pharmacy (generic 'certified U.S. pharmacies')
Medsol RX takes this head-to-head with the higher Desk Score, 76/100 (C) against 62/100 (C) for Lyfe Rx. Lyfe Rx still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Lyfe Rx
62/100
C
Medsol RX
76/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Lyfe Rx | Medsol RX |
|---|---|---|
| Semaglutide | $225/mo (compounded) | $209/mo (compounded) |
| Tirzepatide | $299/mo (compounded) | $250/mo (compounded) |
| Coverage | Not listed on Lyfe Rx's site (checked July 20, 2026) | All 50 states |
| Brand-name | Compounded only | Compounded only |
| Oral option | Injectable only | Injectable only |
| Best for | Readers comparing what GLP-1 programs publish before they commit. | Shoppers who want flexible, HSA/FSA-eligible compounded GLP-1 plans with a care coach. |
| Desk Score | 62/100C | 76/100C |
The verdict
Desk pick — Medsol RXMedsol RX takes this head-to-head with the higher Desk Score, 76/100 (C) against 62/100 (C) for Lyfe Rx. Lyfe Rx still holds its ground where its strengths line up with yours.
Choose Lyfe Rx if…
Readers comparing what GLP-1 programs publish before they commit.
$225/mo (compounded) sema · $299/mo (compounded) tirz
FDAWarning letter issued to Lyfe Rx in September 2025. See the FDA warning-letter database.
Choose Medsol RX if…
Shoppers who want flexible, HSA/FSA-eligible compounded GLP-1 plans with a care coach.
$209/mo (compounded) sema · $250/mo (compounded) tirz · All 50 states
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we file on a provider reads the same either way. Read full breakdowns: Lyfe Rx · Medsol RX.
Also here
CoreAge Rx tops every dispatch at 94/100
Whichever of these two you lean toward, the Desk's #1-rated provider outscores them both. The Desk's top dispatch: one price at every dose, both molecules, all 50 states — but the $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- Lyfe Rx vs CoreAge Rx
- Medsol RX vs Vaylen
- Lyfe Rx vs Strut Health
- Medsol RX vs Ondra Health
- Lyfe Rx vs Invigor Medical
- Medsol RX vs Vytora Health
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.