Head-to-head comparison
Clume Health vs Direct Meds
Two GLP-1 providers, one scorecard. Both are graded on the same six Desk Score dimensions — here is how they stack up, and which one fits you.
Desk Score
Clume Health charges one figure, $259, for either molecule by either route, names four pharmacies with addresses, and advertises two homepage prices it does not sell.
From $259/mo sema · From $259/mo tirz · Verified September 2026
Marked down on: The homepage advertises $199 and $159 a month; the real figures are $259 and $219, and neither advertised number is sold.
Desk Score
A rare compounded desk offering both sublingual drops and injectable on either molecule, at all-inclusive no-membership pricing.
$249/mo sema · $299/mo tirz · Verified August 2026
Marked down on: FDA issued directmeds.com, Inc. dba DirectMeds a warning letter in September 2025; the letter is public in FDA's warning-letter database
FDAWarning letter issued to directmeds.com, Inc. dba DirectMeds in September 2025. See the FDA warning-letter database.
Clume Health takes this head-to-head with the higher Desk Score, 78/100 (C+) against 74/100 (C) for Direct Meds. Direct Meds still holds its ground where its strengths line up with yours.
Desk Score, dimension by dimension
Same six measured dimensions for both. The red flag marks the stronger side. See the methodology.
Clume Health
78/100
C+
Direct Meds
74/100
C
Price transparency
State access
Molecule range
Onboarding speed
Support responsiveness
Licensing & trust
The spec sheet
| Field | Clume Health | Direct Meds |
|---|---|---|
| Semaglutide | From $259/moFrom $259/mo (compounded) | $249/mo$249/mo sublingual · $297/mo injectable |
| Tirzepatide | From $259/moFrom $259/mo (compounded) | $299/mo$299/mo sublingual · $399/mo injectable |
| Coverage | All 50 states and D.C. claimed, no list published | Not listed on Direct Meds's site (checked August 2026) |
| Brand-name | Compounded only | Compounded only |
| Oral option | Yes | Yes |
| Best for | Anyone who wants oral and injectable priced the same and the dispensing pharmacies named. | Patients who want a needle-free sublingual option, or the choice between drops and injection, without a membership fee. |
| Desk Score | 78/100C+ | 74/100C |
The verdict
Desk pick — Clume HealthClume Health takes this head-to-head with the higher Desk Score, 78/100 (C+) against 74/100 (C) for Direct Meds. Direct Meds still holds its ground where its strengths line up with yours.
Choose Clume Health if…
Anyone who wants oral and injectable priced the same and the dispensing pharmacies named.
From $259/mo sema · From $259/mo tirz · All 50 states and D.C. claimed, no list published
Choose Direct Meds if…
Patients who want a needle-free sublingual option, or the choice between drops and injection, without a membership fee.
$249/mo sema · $299/mo tirz
FDAWarning letter issued to directmeds.com, Inc. dba DirectMeds in September 2025. See the FDA warning-letter database.
Assume any provider we list may compensate us — we may earn a referral commission at no extra cost to you, and what we write about a provider reads the same either way. Read full breakdowns: Clume Health · Direct Meds.
Also here
CoreAge Rx leads the whole ranking at 94/100
Whichever of these two you lean toward, our #1-rated provider outscores them both. One price at every dose, both molecules, all 50 states. The $99 and $149 figures are 12-month plans paid up front, not a monthly bill.
More head-to-heads
- Clume Health vs CoreAge Rx
- CoreAge Rx vs Direct Meds
- Clume Health vs MadeMed
- Direct Meds vs Fitish
- Clume Health vs Nolu
- Direct Meds vs MadeMed
Or see the full comparison hub and the complete ranking.
Pricing and verification reflect each provider's public disclosures at last scoring; the Desk Score is our editorial judgment per the methodology. Prices change — confirm on each provider's own site. Not medical advice; see our disclosure.